2025:

He K, Dong X, Yang TJ, Li ZQ, Liu Y, He J, Wu M, Zhang W, Kaysar P, Cui B, Yao X, Zhang L, Zhou W, Xu H, Wei J, Liu Q, Hu J*, Wang X*, Yan H*. Smoking aggravates neovascular age-related macular degeneration via Sema4D-PlexinB1 axis-mediated activation of pericytes. Nature Communications. 2025 Mar 22;16(1):2821.

Lei Y#, Hu J#, Zhao J#, Liu Q, Zhang S-W, Wu F, Liu Y, Ren H, Qin X, Wu X, Gao F, Hu J, Ouyang K, Liu Q, Zheng X, Shi L, Wang X*. Deubiquitinase USP9X controls Wnt-signaling for CNS vascular formation and barrier maintenance. Developmental Cell. 2025 Jan 31:S1534-5807(25)00029-2.

2024:

Ma N, Wu F, Liu J, Wu Z, Wang L, Li B, Liu Y, Dong X, Hu J, Fang X, Zhang H,Ai D, Zhou J*, Wang X*. Kindlin-2 phase separation in response to flow controls vascular stability. Circulation Research. 2024 Dec 6; 135(12):1141-1160.

Yao X#, Li Z#, Lei Y#, Liu Q, Chen S, Zhang H, Dong X, He K, Guo J, Li MJ*, Wang X*, Yan H*. Single-cell multi-omics profiling reveals heterogeneity of Muller cells in the oxygen-induced retinopathy model. Investigative Ophthalmology & Visual Science. 2024 Nov 4;65(13):8.

Lei Y#, Liu Q#, Chen B, Wu F, Li Y, Dong X, Ma N, Wu Z, Zhu Y, Wang L, Fu Y, Liu Y, Song Y, Du M, Zhang H, Zhu J, Lyons T J, Wang T, Hu J, Xu H, Chen M, Yan H*, Wang X*. Protein O-GlcNAcylation coupled to Hippo signaling drives vascular dysfunction in diabetic retinopathy. Nature Communications. 2024 Oct 29;15(1):9334

Chen S#, Liu Y#, Zhang Y, Guo X, Bai T, He K, Zhu Y, Y, Du M, Wang X*, Liu Q*, Yan H*. Bruton’s tyrosine kinase inhibition suppresses pathological retinal angiogenesis. British Journal of Pharmacology. 2024 Oct 7. doi:10.1111/bph.17344Lei.

Liao M#, Zhu X#, Lu Y#, Yi X, Hu Y, Zhao Y, Ye Z, Guo X, Liang M, Jin X, Zhang H, Wang X, Zhao Z*, Chen Y*, Yan H*. Multi-omics profiling of retinal pigment epithelium reveals enhancer-driven activation of RANK-NFATc1 signaling in traumatic proliferative vitreoretinopathy. Nature Communications.15, 7324 (2024)

Dong X#, Song Y#, Liu Y, Kou X, Li Y, Yang T, Yao X, Guo J, He K, Cui B, Wu Z, Lei Y, Du M, Chen M, Xu H, Liu Q*, Shi F*, Wang X*, Yan H*. Natural killer cells promote neutrophil extracellular traps and restrain macular deaeneration in mice. Science Translational Medicine. 2024.16 (760), eadi6626

T Bai#, B Cui#, M Xing, S Chen, Y Zhu, D Lin, Y Guo, M Du, X Wang*, D Zhou* and H Yan*. Stable inhibition of choroidal neovascularization by adeno-associated virus 2/8-vectored bispecific molecules. Gene Therapy. 31, 511–523 (2024).

Zhu J#, Yang W#*, Ma J#, He H#, Liu Z#, Zhu X, He X, He J, Chen Z, Jin X, Wang X, He K, Wei W*, Hu J*. Pericyte signaling via soluble guanylate cyclase shapes the vascular niche and microenvironment of tumors. The EMBO Journal. 2024. 43: 1519 – 154

2023:

Selena W Zhang#, B Cui#, M Xing, J Liu, Y Guo, K He, T Bai, X Dong, Y Lei, W Zhou, H Zhou, S Liu, X Wang*, D Zhou*, H Yan*. Chimpanzee Adenovirus-mediated Multiple Gene Therapy for Age-related Macular Degerenration. iScience. 2023 Sep 16;26(10):107939.

B Cui, X Guo, W Zhou, X Zhang, H He, T Bai, D Lin, S-W Zhang, Y Zhao, S Liu, H Zhou, Q Wang, X Yao, Y Shi, R Xie, X Dong, Y Lei, M Du, Y Chang, H Xu, D Zhou, Y Yu, X Wang*, H Yan*. Exercise alleviates neovascular age-related macular degeneration by inhibiting AIM2 inflammasome in myeloid cells. Metabolism: Clinical and Experimental. 144 (2023) 15584

J Liu #, J Wang#, Y Liu, S Xie, J Zhang, C Zhao, Y Zhou, W Pang, W Yao, Peng Q, Wang X*, Zhou J*. Liquid-Liquid Phase Separation of DDR1 Counteracts the Hippo Pathway to Orchestrate Arterial Stiffening. Circulation Research.(2023) 132(1):87-105

X Yao, H Yang, H Han, X Kou, Y Jiang, M Luo, Y Zhou, J Wang, X Fan, X Wang*, MJ Li*, H Yan*. Genome-wide analysis of genetic pleiotropy and causal genes across three age-related ocular disorders. Human Genetics.(2023)142, 507–522

X Yang #, ST Wu #, R Gao, R Wang, Y Wang, Z Dong, L Wang, C Qi, X Wang, ML Schmitz, R Liu, Z Han, L Wang, X Zheng*. Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation. JCI insight. (2023) 8(5):e160372.

X Meng, Q Wang, S Chen, S Zhang, J Yu, H Li, X Chen, Z Wang, W Yu, Z Zheng, H Zhou, J Luo, Z Wang, H Chen, N Wu, D Hu, S Chen, Y Wei, H Cui, H Song, H Chen, Y Wang, J Zhong, Z Chen, H Zhang, T Yang, M Li, Y Liu, X Dong, M Du, X Wang, X Yao, H Lin*, MJ Li*, H Yan*. An interpretable model predicts visual outcomes of no light perception eyes after open globe injury. British Journal of Ophthalmology. (2023) 3:bjo-2022-322753.

2022:

Y Zhao #, Y Lei #, H Ning#, Y Zhang, G Chen, C Wang, Q Wan, S Guo, Q Liu, R Xie, Y Zhuo, S Yan, J Zhao, F Wei, L Wang, X Wang, W Li, H Yan*, Y Yu*. PGF2α facilitates pathological retinal angiogenesis by modulating endothelial FOS‐driven ELR+ CXC chemokine expression. EMBO Molecular Medicine. (2022) e16373.

M Guo#, Y Zhu#, Y Shi, X Meng, X Dong, H Zhang, X Wang*, M Du*, H Yan*. Inhibition of ferroptosis promotes retina ganglion cell survival in experimental optic neuropathies. Redox Biology. (2022) 58: 102541.

H He#, W Yang#, N Su#, C Zhang, J Dai, F Han, M Singhal, W Bai, X Zhu, J Zhu, Z Liu, W Xia, X Liu, C Zhang, K Jiang, W Huang, D Chen, Z Wang, X He, F Kirchhoff, Z Li, C Liu, J Huan, X Wang, W Wei, J Wang, HG Augustin, J Hu*. Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury. Journal of Experimental Medicine(2022) 220 (2), e20211422

Y Song, H Zhang, Y Zhu, X Zhao, Y Lei, W Zhou, J Yu, X Dong, X Wang, M Du*, H Yan*. Lysozyme Protects Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Inflammation in Human Corneal Epithelial Cells. Investigative Ophthalmology & Visual Science. (2022) 63 (6), 16-16

C Zhang, H He, J Dai, Y Li, J He, W Yang, J Dai, F Han, W Kong, X Wang, X Zheng, J Zhou, W Pan, Z Chen, S Mahak, Y Zhang, F Guo*, J Hu*. KANK4 Promotes Arteriogenesis by Potentiating VEGFR2 Signaling in a TALIN-1–Dependent Manner. Arteriosclerosis, Thrombosis, and Vascular Biology. (2022) 122.317711.

2021:

Y Shen #, X Wang #*, Y Liu, M Singhal, C Gürkaşlar, A Freire Valls, L Lei, W Hu, G Schermann, H Adler, F Yu, T Fischer, Y Zhu, H Augustin, T Schmidt*, C Ruiz de Almodóvar *. STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis. Science Signaling. (2021) 14, eabj8393.

X Dong #, Y Lei #, Z Yu, T Wang, Y Liu, G Han, X Zhang, Y Li, Y Song, H Xu, M Du, H Yin, X Wang * and H Yan*. Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis. Theranostics. (2021). 11(11):5107-5126

X Jiang#, J Hu#. Z Wu, SC Cafarello, MD Matteo, Y Shen, X Dong, H Adler, M Mazzone, C Ruiz de Almodovar *, X Wang*. Protein phosphatase2 (PP2A) mediates YAP activation in endothelial cells upon VEGF stimulation and matrix stiffness. Front. Cell. Dev. Biol. (2021) doi: 10.3389/fcell.2021.675562.

T Wang#, Y Li#, M Guo, M Du, X Wang*, H Yin*, H Yan*. Exosome-mediated delivery of neuroprotective peptide PACAP38 promotes retina ganglion cells survival and axon regeneration in rats with traumatic optic neuropathy. Front. Cell. Dev. Biol. (2021) 9:659783. doi: 10.3389/fcell.2021.659783.

S Zhu, Z Chen, M Zhu, Y Shen, LJ Leon, L Chi, S Spinozzi, C Tan, Y Gu, A Nguyen, Y Zhou, W Feng, FM Vaz, X Wang, AB Gustafsson, SM Evans, O Kunfu*, X Fang* Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy. Circulation: Heart Failure. (2021) 14 (6), e008289

H Han #, X Zhao #, M Liao, Y Song, C You, X Dong, X Yang, X Wang, B Huang, M Du*, H Yan*. Activated Blood Coagulation Factor X (FXa) Contributes to the Development of Traumatic PVR Through Promoting RPE Epithelial-Mesenchymal Transition. Investigative Ophthalmology & Visual Science(2021) 62 (9), 29-29

Y Song #, M Liao #, X Zhao, H Han, X Dong, X Wang, M Du*, H Yan*. Vitreous M2 Macrophage-Derived Microparticles Promote RPE Cell Proliferation and Migration in Traumatic Proliferative Vitreoretinopathy. Investigative Ophthalmology & Visual Science. 62 (2021) (12), 26-26.

J Li #, R Xie #, F Jiang #, Y Li, Y Zhu, Z Liu, M Liao, Y Liu, X Meng, S Chen, J Yu, M Du, X Wang, Y Chen*, H Yan*. Tumor necrosis factor ligand‐related molecule 1A maintains blood–retinal barrier via modulating SHP1-Src-VE-cadherin signaling in diabetic retinopathy. The FASEB Journal (2021) 35 (11), e22008

Before 2020

Y Shen#, X Wang #, J Lu, M Salfenmoser, N. M Wirsik, N Schleussner, A Imle, A Freire-Valls, P Radhakrishnan, J Jie Liang, G Wang, T Muley, M Schneider, C Ruiz de Almodovar, A Diz-Munoz*, T Schmidt *. Reduction of liver metastasis stiffness improves response to bevacizumab in metastatic colorectal cancer. (2020) Cancer Cell 37, 800-817.

N Tisch #, A Freire-Valls #, R Yerbes #, I Paredes, S La Porta, X Wang, R Martín-Pérez, L Castro, W Wei-Lynn Wong, L Coultas, B Strilic, HJ Gröne, T Hielscher, C Mogler, RH Adams, P Heiduschka, L Claesson-Welsh, M Mazzone, A López-Rivas, T Schmidt, H G Augustin, C Ruiz de Almodovar*. Caspase-8 modulates physiological and pathological angiogenesis during retina development. The Journal of clinical investigation (2019) 129 (12)

X Wang, A Freire Valls, G Shermann, Y Shen, IM Moya, L Castro, S Urban, GM Solecki, F Winkler, L Riedemann, RK Jain, M Mazzone, T Schmidt, T Fischer, G Halder, C Ruiz de Almodovar. YAP/TAZ orchestrate VEGF signaling during developmental angiogenesis. Developmental Cell.  (2017) Sep 11;42(5):462-478.e7. (Highlighted by Journal. F1000Prime recommended.)

X Fang, L Fang, A Liu, X Wang, B Zhao, N Wang. Activation of PPAR‐δ induces microRNA‐100 and decreases the uptake of very low-density lipoprotein in endothelial cells. British journal of pharmacology. (2015) 172 (15), 3728-3736

X Wang #, X Fang #, J Zhou, Z Chen, B Zhao, L Xiao, A Liu, YSJ Li, J-YJ Shyy, Y Guan, S Chien *, N Wang * Shear stress activation of nuclear receptor PXR in endothelial detoxification. Proc Natl Acad Sci U S A. (2013);110(32):13174-9.

X Qin #, X Wang, Y Wang, Z Tang, Q Cui, J Xi, Y-SJ Li, S Chien *, and N Wang *. MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells. Proc Natl Acad Sci U S A. (2010) Feb 16;107(7):3240-4.